Diminished force production and mitochondrial respiratory deficits are strain-dependent myopathies of subacute limb ischemia
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چکیده
منابع مشابه
Mitochondrial myopathies: deficiencies localized to complex I and complex III of the mitochondrial respiratory chain.
Deficiencies of the mitochondrial respiratory chain or the phosphorylation system are becoming increasingly recognized causes of myopathy and multisystem disease in man. In biochemical terms, the ones most clearly defined have been associated with impaired activities of NADH : ubiquinone reductase (Morgan-Hughes el al., 1979, 1984; Land et al., 1981; Moreadith etal., 1984), ubiquino1:cytochrome...
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SIR—In several hundreds of patients with a mitochondrial myopathy an enzyme defect in mitochondrial energy metabolism is identified. However, in a substantial number of subjects no enzyme defect can be detected, although diminished substrate oxidation and ATP production rates are found in their muscle in vitro. The hypothesis, that in this group of patients proteins for transport of vario...
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Pearson syndrome. Clinical spectrum of mitochondrial disorders is broad, so consensus diagnostic criteria for mitochondrial disorders have been proposed for children and adults. Sequence map of human mitochondrial genome with its normal and patho genic variants is publicly available. In this review, we will discuss genetic features of mitochondrial myopathies as well as their key findings. Rep...
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Critical limb ischemia (CLI) is the most severe clinical presentation of peripheral arterial disease and manifests as chronic limb pain at rest and/or tissue necrosis. Current clinical interventions are largely ineffective and therapeutic angiogenesis based trials have shown little efficacy, highlighting the dire need for new ideas and novel therapeutic approaches. Despite a decade of research ...
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In this prospective descriptive study, all patients with acute lower limb ischemia who presented to Shohada Tajrish Hospital (STH) between July 200 1 and July 2003 were analyzed and followed for 6 months. The total population of 109 patients, with no significant difference in sexual distribution had a mean age of 64± 16 years. 23% had AF and 31 % had a history of MI, 'but in the ECG of 30%,...
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ژورنال
عنوان ژورنال: Journal of Vascular Surgery
سال: 2017
ISSN: 0741-5214
DOI: 10.1016/j.jvs.2016.04.041